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The methyl group works like a placeholder in a cookbook, attaching to the DNA within each cell to select only those recipes — er, genes — necessary for that particular cell’s proteins.
Because methyl groups are attached to the genes, residing beside but separate from the double-helix DNA code, the field was dubbed epigenetics, from the prefix (Greek for over, outer, above).
“It’s all about the tactile stimulation,” Meaney says. Two alcoholic mice — a mother and her son — sit on two bar stools, lapping gin from two thimbles.The mother mouse looks up and says, “Hey, geniuses, tell me how my son got into this sorry state.” “Bad inheritance,” says Darwin. For over a hundred years, those two views — nature or nurture, biology or psychology — offered opposing explanations for how behaviors develop and persist, not only within a single individual but across generations.Sometimes methyl groups attached to DNA thanks to changes in diet; other times, exposure to certain chemicals appeared to be the cause.Szyf showed that correcting epigenetic changes with drugs could cure certain cancers in animals.
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And then, in 1992, two young scientists following in Freud’s and Darwin’s footsteps actually did walk into a bar.